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Research Article Free access | 10.1172/JCI105675

Hemoglobin Yakima: II. High Blood Oxygen Affinity Associated with Compensatory Erythrocytosis and Normal Hemodynamics

Miles J. Novy, Miles J. Edwards, and James Metcalfe

Heart Research Laboratory and Division of Chest Diseases, Department of Medicine, University of Oregon Medical School, Portland, Oregon

‡

Research Associate, National Institute of Child Health and Human Development. Present address: Dept. of Surgery, Boston University School of Medicine, Boston, Mass.

§

Professor of Medicine, Oregon Heart Association Chair of Cardiovascular Research. Address requests for reprints to Dr. James Metcalfe, Heart Research Laboratory, University of Oregon Medical School, Portland, Oreg. 97201.

*

Received for publication 16 May 1967 and in revised form 23 June 1967.

Supported by Training Grant No. HE 5499, Research Grant No. HE 06042, and Cardiovascular Program Project Grant No. HE 06336 of the National Heart Institute and by funds from the National Institute of Child Health and Human Development.

Presented in part at the Twentieth Annual Meeting of the Western Society for Clinical Research, 26 January 1967, at Carmel, Calif.

Find articles by Novy, M. in: PubMed | Google Scholar

Heart Research Laboratory and Division of Chest Diseases, Department of Medicine, University of Oregon Medical School, Portland, Oregon

‡

Research Associate, National Institute of Child Health and Human Development. Present address: Dept. of Surgery, Boston University School of Medicine, Boston, Mass.

§

Professor of Medicine, Oregon Heart Association Chair of Cardiovascular Research. Address requests for reprints to Dr. James Metcalfe, Heart Research Laboratory, University of Oregon Medical School, Portland, Oreg. 97201.

*

Received for publication 16 May 1967 and in revised form 23 June 1967.

Supported by Training Grant No. HE 5499, Research Grant No. HE 06042, and Cardiovascular Program Project Grant No. HE 06336 of the National Heart Institute and by funds from the National Institute of Child Health and Human Development.

Presented in part at the Twentieth Annual Meeting of the Western Society for Clinical Research, 26 January 1967, at Carmel, Calif.

Find articles by Edwards, M. in: PubMed | Google Scholar

Heart Research Laboratory and Division of Chest Diseases, Department of Medicine, University of Oregon Medical School, Portland, Oregon

‡

Research Associate, National Institute of Child Health and Human Development. Present address: Dept. of Surgery, Boston University School of Medicine, Boston, Mass.

§

Professor of Medicine, Oregon Heart Association Chair of Cardiovascular Research. Address requests for reprints to Dr. James Metcalfe, Heart Research Laboratory, University of Oregon Medical School, Portland, Oreg. 97201.

*

Received for publication 16 May 1967 and in revised form 23 June 1967.

Supported by Training Grant No. HE 5499, Research Grant No. HE 06042, and Cardiovascular Program Project Grant No. HE 06336 of the National Heart Institute and by funds from the National Institute of Child Health and Human Development.

Presented in part at the Twentieth Annual Meeting of the Western Society for Clinical Research, 26 January 1967, at Carmel, Calif.

Find articles by Metcalfe, J. in: PubMed | Google Scholar

Published November 1, 1967 - More info

Published in Volume 46, Issue 11 on November 1, 1967
J Clin Invest. 1967;46(11):1848–1854. https://doi.org/10.1172/JCI105675.
© 1967 The American Society for Clinical Investigation
Published November 1, 1967 - Version history
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Abstract

Erythrocytosis without clinical illness was noted in a man and his two daughters. Their blood contained approximately 62% hemoglobin A and 38% a new hemoglobin, designated hemoglobin Yakima. The oxygen affinity of whole blood from each subject was greatly increased and heme-heme interactions were impaired. At 37°C and a plasma pH of 7.40, the oxygen pressure required to produce 50% saturation of hemoglobin with oxygen was only 12 mm Hg as compared with a normal of 26 mm Hg. The high oxygen affinity of this blood is attributed to the presence of hemoglobin Yakima; and the increased oxygen affinity was shown to be characteristic of the isolated abnormal hemoglobin. A Bohr effect was present in hemoglobin Yakima.

Arterial oxygen pressure, oxygen consumption, and cardiac output at rest were normal. With respect to oxygen delivery to tissues, the increased hemoglobin concentration appears to be the major compensation for the marked displacement of the oxygen-hemoglobin equilibrium curve, although other factors may contribute. The finding of high normal quantities of erythropoietin in the urine is consistent with this degree of erythrocytosis.

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