Go to JCI Insight
Jci spelled out white on transparent.20160208
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Alerts
  • Advertising/recruitment
  • Subscribe
  • Contact
  • Current Issue
  • Past Issues
  • By specialty
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All...
  • Videos
    • Conversations with Giants in Medicine
    • Author's Takes
  • Reviews
    • View all reviews...
    • Biology of familial cancer predisposition syndromes (Feb 2019)
    • Mitochondrial dysfunction in disease (Aug 2018)
    • Lipid mediators of disease (Jul 2018)
    • Cellular senescence in human disease (Apr 2018)
    • Fibrosis (Jan 2018)
    • Glia and Neurodegeneration (Sep 2017)
    • Transplantation (Jun 2017)
    • View all review series...
  • Collections
    • Recently published
    • In-Press Preview
    • Commentaries
    • Concise Communication
    • Editorials
    • Viewpoint
    • Scientific Show Stoppers
    • Top read articles
  • Clinical Medicine
  • JCI This Month
    • Current issue
    • Past issues

Jci only white

  • About
  • Editors
  • Consulting Editors
  • For authors
  • Current issue
  • Past issues
  • By specialty
  • Subscribe
  • Alerts
  • Advertise
  • Contact
  • Conversations with Giants in Medicine
  • Author's Takes
  • Recently published
  • Brief Reports
  • Technical Advances
  • Commentaries
  • Editorials
  • Hindsight
  • Review series
  • Reviews
  • The Attending Physician
  • First Author Perspectives
  • Scientific Show Stoppers
  • Top read articles
  • Concise Communication
Top
  • View PDF Adobe pdf file icon
  • Download citation information
  • Send a letter
  • License information
  • Standard abbreviations
  • Article usage
  • Citations to this article
  • Share this article
  • Need Help? E-mail the JCI
  • Top
  • Abstract
  • Version history
Advertisement

Research Article Free access | 10.1172/JCI105669

The Relation of Immunoglobulin Class, Pattern of Antinuclear Antibody, and Complement-Fixing Antibodies to DNA in Sera from Patients with Systemic Lupus Erythematosus

Naomi F. Rothfield and B. David Stollar

Department of Medicine, New York University School of Medicine, New York

Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts

‡

Clinical Scholar, The Arthritis Foundation.

Address requests for reprints to Dr. Naomi Rothfield, New York University Medical Center, School of Medicine, Department of Medicine, 550 First Avenue, New York, N. Y. 10016.

*

Received for publication 2 May 1967 and in revised form 14 July 1967.

Presented in part at a joint meeting of the American Society for Clinical Investigation and the American Federation for Clinical Research on 30 April 1967 in Atlantic City, N. J.

This study was supported by grants from the National Institute of Allergy and Infectious Diseases (AI 06853), the Lupus Foundation, and the National Science Foundation (GB 5606).

Find articles by Rothfield, N. in: JCI | PubMed | Google Scholar

Department of Medicine, New York University School of Medicine, New York

Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts

‡

Clinical Scholar, The Arthritis Foundation.

Address requests for reprints to Dr. Naomi Rothfield, New York University Medical Center, School of Medicine, Department of Medicine, 550 First Avenue, New York, N. Y. 10016.

*

Received for publication 2 May 1967 and in revised form 14 July 1967.

Presented in part at a joint meeting of the American Society for Clinical Investigation and the American Federation for Clinical Research on 30 April 1967 in Atlantic City, N. J.

This study was supported by grants from the National Institute of Allergy and Infectious Diseases (AI 06853), the Lupus Foundation, and the National Science Foundation (GB 5606).

Find articles by Stollar, B. in: JCI | PubMed | Google Scholar

First published November 1, 1967 - More info

Published in Volume 46, Issue 11 on November 1, 1967
J Clin Invest. 1967;46(11):1785–1794. https://doi.org/10.1172/JCI105669.
Copyright © 1967, The American Society for Clinical Investigation.

First published November 1, 1967 - Version history
Abstract

Sera from 55 patients with systemic lupus erythematosus were studied to clarify the significance of the patterns of nuclear fluorescence observed. The sera in which the IgG fraction produced a peripheral pattern of nuclear fluorescence were found to contain complement-fixing antibodies to native DNA and to DNA-histone complexes. This correlation did not exist when complement-fixing activity was compared to the IgM nuclear patterns. Sera which contained only complement-fixing antibodies to denatured DNA and which did not react with native DNA or nucleoprotein did not produce the peripheral pattern of nuclear fluorescence. The data suggest that single strands of DNA were not the reactive groups in the nucleus responsible for the peripheral pattern. The results support the conclusion that DNA within a DNA-protein complex may be the nuclear antigen responsible for the peripheral pattern of nuclear fluorescence.

Analysis of the clinical data revealed that a close correlation existed between the presence of IgG peripheral pattern, complement-fixing antibodies to DNA and histone-DNA complexes, and clinical manifestation of active disease.

Images
Browse pages

Click on an image below to see the page. View PDF of the complete article

icon of scanned page 1785
page 1785
icon of scanned page 1786
page 1786
icon of scanned page 1787
page 1787
icon of scanned page 1788
page 1788
icon of scanned page 1789
page 1789
icon of scanned page 1790
page 1790
icon of scanned page 1791
page 1791
icon of scanned page 1792
page 1792
icon of scanned page 1793
page 1793
icon of scanned page 1794
page 1794
Version history
  • Version 1 (November 1, 1967): No description

Article tools

  • View PDF Adobe pdf file icon
  • Download citation information
  • Send a letter
  • License information
  • Standard abbreviations
  • Article usage
  • Citations to this article
  • Share this article
  • Need Help? E-mail the JCI

Go to:

  • Top
  • Abstract
  • Version history
Advertisement
Advertisement
Follow JCI: Facebook logo white Twitter logo v2 Rss icon
Copyright © 2019 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts