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Usage Information

Difference in Hepatic Metabolism of Long- and Medium-Chain Fatty Acids: the Role of Fatty Acid Chain Length in the Production of the Alcoholic Fatty Liver
Charles S. Lieber, … , Lawrence Feinman, Leonore M. DeCarli
Charles S. Lieber, … , Lawrence Feinman, Leonore M. DeCarli
Published September 1, 1967
Citation Information: J Clin Invest. 1967;46(9):1451-1460. https://doi.org/10.1172/JCI105637.
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Research Article

Difference in Hepatic Metabolism of Long- and Medium-Chain Fatty Acids: the Role of Fatty Acid Chain Length in the Production of the Alcoholic Fatty Liver

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Abstract

Replacement of dietary triglycerides containing long-chain fatty acids (LCFA) by triglycerides containing medium-chain fatty acids (MCFA) markedly reduced the capacity of alcohol to produce fatty liver in rats. After 24 days of ethanol and MCFA, the increase in hepatic triglycerides was only 3 times that of controls, whereas an 8-fold rise was observed after ethanol and LCFA. The triglyceride fatty acids that accumulated in the liver after feeding of ethanol with MCFA contained only a small percentage of the MCFA; their composition also differed strikingly from that of adipose lipids.

Authors

Charles S. Lieber, André Lefèvre, Norton Spritz, Lawrence Feinman, Leonore M. DeCarli

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Usage data is cumulative from July 2024 through July 2025.

Usage JCI PMC
Text version 447 11
PDF 131 18
Scanned page 440 10
Citation downloads 58 0
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Total Views 1,115
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