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Usage Information

Impaired Lymphocyte Transformation and Delayed Hypersensitivity in Sjögren's Syndrome
Brigid G. Leventhal, … , Donald S. Waldorf, Norman Talal
Brigid G. Leventhal, … , Donald S. Waldorf, Norman Talal
Published August 1, 1967
Citation Information: J Clin Invest. 1967;46(8):1338-1345. https://doi.org/10.1172/JCI105626.
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Research Article

Impaired Lymphocyte Transformation and Delayed Hypersensitivity in Sjögren's Syndrome

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Abstract

In vitro lymphocyte transformation in response to phytohemagglutinin and streptolysin O and in vivo skin sensitization to 2,4-dinitrochloro-benzene has been studied in patients with Sjögren's syndrome and in normal controls of comparable age and sex. Both the in vivo and in vitro responses were significantly impaired in the Sjögren's patients as compared to the controls. This lack of response to mitogenic agents is probably due to an intrinsic defect in the lymphocytes rather than to a serum factor. The abnormalities were less marked in patients whose disease was localized to the parotid and lacrimal glands than in those with generalized disease, i.e., with complicating rheumatoid arthritis or pseudolymphoma.

Authors

Brigid G. Leventhal, Donald S. Waldorf, Norman Talal

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Usage data is cumulative from August 2024 through August 2025.

Usage JCI PMC
Text version 166 4
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Scanned page 482 4
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