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Research Article Free access | 10.1172/JCI105617
Department of Medicine, Harvard Medical School, Boston, Mass
Department of Surgery, Harvard Medical School, Boston, Mass
Department of Medicine, Peter Bent Brigham Hospital, Boston, Mass
Department of Surgery, Peter Bent Brigham Hospital, Boston, Mass
†Work performed during a medical fellowship from the Nuffield Foundation.
Address requests for reprints to Dr. Stanley M. Rosen, The General Infirmary, Leeds 1, England.
‡Work performed during a fellowship from the Massachusetts Heart Association.
*Submitted for publication July 5, 1966; accepted April 13, 1967.
A partial report of this work was read at the Surgical Forum of the American College of Surgeons on October 20, 1965.
Find articles by Rosen, S. in: JCI | PubMed | Google Scholar
Department of Medicine, Harvard Medical School, Boston, Mass
Department of Surgery, Harvard Medical School, Boston, Mass
Department of Medicine, Peter Bent Brigham Hospital, Boston, Mass
Department of Surgery, Peter Bent Brigham Hospital, Boston, Mass
†Work performed during a medical fellowship from the Nuffield Foundation.
Address requests for reprints to Dr. Stanley M. Rosen, The General Infirmary, Leeds 1, England.
‡Work performed during a fellowship from the Massachusetts Heart Association.
*Submitted for publication July 5, 1966; accepted April 13, 1967.
A partial report of this work was read at the Surgical Forum of the American College of Surgeons on October 20, 1965.
Find articles by Truniger, B. in: JCI | PubMed | Google Scholar
Department of Medicine, Harvard Medical School, Boston, Mass
Department of Surgery, Harvard Medical School, Boston, Mass
Department of Medicine, Peter Bent Brigham Hospital, Boston, Mass
Department of Surgery, Peter Bent Brigham Hospital, Boston, Mass
†Work performed during a medical fellowship from the Nuffield Foundation.
Address requests for reprints to Dr. Stanley M. Rosen, The General Infirmary, Leeds 1, England.
‡Work performed during a fellowship from the Massachusetts Heart Association.
*Submitted for publication July 5, 1966; accepted April 13, 1967.
A partial report of this work was read at the Surgical Forum of the American College of Surgeons on October 20, 1965.
Find articles by Kriek, H. in: JCI | PubMed | Google Scholar
Department of Medicine, Harvard Medical School, Boston, Mass
Department of Surgery, Harvard Medical School, Boston, Mass
Department of Medicine, Peter Bent Brigham Hospital, Boston, Mass
Department of Surgery, Peter Bent Brigham Hospital, Boston, Mass
†Work performed during a medical fellowship from the Nuffield Foundation.
Address requests for reprints to Dr. Stanley M. Rosen, The General Infirmary, Leeds 1, England.
‡Work performed during a fellowship from the Massachusetts Heart Association.
*Submitted for publication July 5, 1966; accepted April 13, 1967.
A partial report of this work was read at the Surgical Forum of the American College of Surgeons on October 20, 1965.
Find articles by Murray, J. in: JCI | PubMed | Google Scholar
Department of Medicine, Harvard Medical School, Boston, Mass
Department of Surgery, Harvard Medical School, Boston, Mass
Department of Medicine, Peter Bent Brigham Hospital, Boston, Mass
Department of Surgery, Peter Bent Brigham Hospital, Boston, Mass
†Work performed during a medical fellowship from the Nuffield Foundation.
Address requests for reprints to Dr. Stanley M. Rosen, The General Infirmary, Leeds 1, England.
‡Work performed during a fellowship from the Massachusetts Heart Association.
*Submitted for publication July 5, 1966; accepted April 13, 1967.
A partial report of this work was read at the Surgical Forum of the American College of Surgeons on October 20, 1965.
Find articles by Merrill, J. in: JCI | PubMed | Google Scholar
Published July 1, 1967 - More info
Serial measurements of intrarenal distribution of blood flow have been recorded in anesthetized dogs with the 133xenon “washout” technique. The results showed that normal kidneys redistributed their blood flow after laparotomy and mobilization of the kidney. This alteration consisted of a diminution in percentage of total renal blood flow supplied to the fastest flowing component, and a diminution of renal mass supplied by that component. This effect lasted for as long as 7 days. Thereafter, the blood flow distribution remained stable.
Autotransplanted kidneys had a stable distribution of blood flow between 0 and 77 days after operation, the values being identical with the stable normal kidney. Homotransplanted kidneys had the same intrarenal distribution of blood flow after operation as the autotransplanted kidneys. Whereas the intrarenal distribution of blood flow of the autotransplanted kidneys remained stable, a redistribution occurred in the homotransplanted kidneys as rejection progressed. This phenomenon occurred before marked elevation of blood urea nitrogen.
The redistribution was due to a decrease in percentage of blood flow supplied to the fastest flowing component, and a relative reduction of tissue mass perfused by this component.
Radioautography of the kidneys before rejection demonstrated that the cortex was homogeneously perfused by the fastest flowing component of blood flow. As rejection progressed, a reduced area of cortex was perfused by this component. Terminally, the fastest flowing component was located in the outer medulla.
It is suggested that the reduction in cortical blood flow produced by immunological mechanisms may play a prominent role in the ensuing renal failure.
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