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Usage Information

Ceruloplasmin in Wilson's Disease
Neil A. Holtzman, … , Frank L. Iber, Bonnie M. Gaumnitz
Neil A. Holtzman, … , Frank L. Iber, Bonnie M. Gaumnitz
Published June 1, 1967
Citation Information: J Clin Invest. 1967;46(6):993-1002. https://doi.org/10.1172/JCI105606.
View: Text | PDF
Research Article

Ceruloplasmin in Wilson's Disease

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Abstract

Ceruloplasmin was highly purified from one patient with Wilson's disease and partially purified from a second unrelated patient. The highly purified ceruloplasmin was indistinguishable from normal ceruloplasmin by electrophoresis, tryptic peptide map, oxidase activity, and copper, amino acid, and sugar composition. The partially purified ceruloplasmin was indistinguishable electrophoretically from normal ceruloplasmin. With penicillamine therapy, ceruloplasmin disappeared from the serum of the first patient; it reappeared after the drug was discontinued. The significance of this observation in regard to the basic defect in Wilson's disease is discussed.

Authors

Neil A. Holtzman, Michael A. Naughton, Frank L. Iber, Bonnie M. Gaumnitz

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Usage data is cumulative from June 2024 through June 2025.

Usage JCI PMC
Text version 112 22
PDF 52 12
Scanned page 367 1
Citation downloads 74 0
Totals 605 35
Total Views 640
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