Bacterial Interference in Chick Embryos

John C. Ribble; Henry R. Shinefield

doi:10.1172/JCI105546

Department of Medicine, The New York Hospital-Cornell Medical Center, New York, N. Y.

†

Career scientist of the Health Research Council of the City of New York. Address requests for reprints to Dr. John C. Ribble, Dept. of Pediatrics, The New York Hospital-Cornell Medical Center, 525 E. 68th St., New York, N. Y. 10021.

Submitted for publication April 25, 1966; accepted December 1, 1966.

A partial report of this work appeared in abstract form (J. clin. Invest. 1964, 43, 1272).

Supported by U. S. Public Health Service grants AI-06220 and TI-255, and grant U-1248 from the Health Research Council of the City of New York.

Find articles by Ribble, J. in: PubMed | Google Scholar

Department of Medicine, The New York Hospital-Cornell Medical Center, New York, N. Y.

†

Submitted for publication April 25, 1966; accepted December 1, 1966.

A partial report of this work appeared in abstract form (J. clin. Invest. 1964, 43, 1272).

Supported by U. S. Public Health Service grants AI-06220 and TI-255, and grant U-1248 from the Health Research Council of the City of New York.

Find articles by Shinefield, H. in: PubMed | Google Scholar

Published in Volume 46, Issue 3 on March 1, 1967
J Clin Invest. 1967;46(3):446–452. https://doi.org/10.1172/JCI105546.
© 1967 The American Society for Clinical Investigation

Published March 1, 1967 - Version history

Chick embryos infected intra-allantoically with nonvirulent staphylococci are protected from death due to infection with virulent staphylococci. The protection is associated with a delay in growth of the challenge strain and a delay in the production of toxic substances in the allantoic fluid. The protection is influenced by the number of bacteria in the protecting and challenge inocula and by the interval between the administration of the protecting and challenge strains. Protection cannot be transferred by administration of sterile filtrates of allantoic fluid in which the protecting strain has grown.