Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Alerts
  • Advertising
  • Job board
  • Subscribe
  • Contact
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Author's Takes
  • Reviews
    • View all reviews ...
    • Immune Environment in Glioblastoma (Feb 2023)
    • Korsmeyer Award 25th Anniversary Collection (Jan 2023)
    • Aging (Jul 2022)
    • Next-Generation Sequencing in Medicine (Jun 2022)
    • New Therapeutic Targets in Cardiovascular Diseases (Mar 2022)
    • Immunometabolism (Jan 2022)
    • Circadian Rhythm (Oct 2021)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Commentaries
    • Research letters
    • Letters to the editor
    • Editorials
    • Viewpoint
    • Top read articles
  • Clinical Medicine
  • JCI This Month
    • Current issue
    • Past issues

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Author's Takes
  • In-Press Preview
  • Commentaries
  • Research letters
  • Letters to the editor
  • Editorials
  • Viewpoint
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Alerts
  • Advertising
  • Job board
  • Subscribe
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a comment
  • Share this article
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal
  • Top
  • Abstract
  • Version history
  • Article usage
  • Citations to this article

Advertisement

Research Article Free access | 10.1172/JCI105504

Increased Plasma Arginine Vasopressin in Clinical Adrenocortical Insufficiency and Its Inhibition By Glucosteroids

Abdul B. J. Ahmed, Barbara C. George, Carlos Gonzalez-Auvert, and Joseph F. Dingman

Lahey Clinic Foundation Endocrine Research Unit, Robert B. Brigham Hospital, and the Department of Medicine, Peter Bent Brigham Hospital and Harvard Medical School, Boston, Mass.

†

Address requests for reprints to Dr. Joseph F. Dingman, Peter Bent Brigham Hospital, 721 Huntington Ave., Boston, Mass. 02115.

*

Submitted for publication February 4, 1966; accepted September 28, 1966.

Supported in part by U. S. Public Health Service grants HE06965 and AM05577.

Dedicated to Dr. George W. Thorn on his sixtieth birthday.

A preliminary report of this work has been published in abstract form (1).

Find articles by Ahmed, A. in: JCI | PubMed | Google Scholar

Lahey Clinic Foundation Endocrine Research Unit, Robert B. Brigham Hospital, and the Department of Medicine, Peter Bent Brigham Hospital and Harvard Medical School, Boston, Mass.

†

Address requests for reprints to Dr. Joseph F. Dingman, Peter Bent Brigham Hospital, 721 Huntington Ave., Boston, Mass. 02115.

*

Submitted for publication February 4, 1966; accepted September 28, 1966.

Supported in part by U. S. Public Health Service grants HE06965 and AM05577.

Dedicated to Dr. George W. Thorn on his sixtieth birthday.

A preliminary report of this work has been published in abstract form (1).

Find articles by George, B. in: JCI | PubMed | Google Scholar

Lahey Clinic Foundation Endocrine Research Unit, Robert B. Brigham Hospital, and the Department of Medicine, Peter Bent Brigham Hospital and Harvard Medical School, Boston, Mass.

†

Address requests for reprints to Dr. Joseph F. Dingman, Peter Bent Brigham Hospital, 721 Huntington Ave., Boston, Mass. 02115.

*

Submitted for publication February 4, 1966; accepted September 28, 1966.

Supported in part by U. S. Public Health Service grants HE06965 and AM05577.

Dedicated to Dr. George W. Thorn on his sixtieth birthday.

A preliminary report of this work has been published in abstract form (1).

Find articles by Gonzalez-Auvert, C. in: JCI | PubMed | Google Scholar

Lahey Clinic Foundation Endocrine Research Unit, Robert B. Brigham Hospital, and the Department of Medicine, Peter Bent Brigham Hospital and Harvard Medical School, Boston, Mass.

†

Address requests for reprints to Dr. Joseph F. Dingman, Peter Bent Brigham Hospital, 721 Huntington Ave., Boston, Mass. 02115.

*

Submitted for publication February 4, 1966; accepted September 28, 1966.

Supported in part by U. S. Public Health Service grants HE06965 and AM05577.

Dedicated to Dr. George W. Thorn on his sixtieth birthday.

A preliminary report of this work has been published in abstract form (1).

Find articles by Dingman, J. in: JCI | PubMed | Google Scholar

Published January 1, 1967 - More info

Published in Volume 46, Issue 1 on January 1, 1967
J Clin Invest. 1967;46(1):111–123. https://doi.org/10.1172/JCI105504.
© 1967 The American Society for Clinical Investigation
Published January 1, 1967 - Version history
View PDF
Abstract

Trichloroacetic acid extracts of plasma were fractionated on a CG-50 resin column and the 50% acetic acid eluents chromatographed on silicic acid-impregnated glass paper in butanol-acetic acid-water. The specific arginine vasopressin (AVP) zone was eluted and assayed for antidiuretic activity in the diuretic rat. Thioglycolate inactivation was used to confirm AVP activity. Recovery of as little as 4 μU AVP per ml plasma ranged between 80 and 90%. In normal subjects after an overnight fast, plasma AVP ranged between 2.5 and 10.0 μU per ml. AVP secretion was inhibited by hemodilution and stimulated with nicotine and hypertonic saline. Plasma AVP was absent in patients with diabetes insipidus even after neurohypophyseal stimulation. Plasma AVP was abnormally elevated during mild dehydration and remained above the normal range despite hemodilution in patients with untreated adrenocortical insufficiency demonstrating a delayed water diuresis. Glucosteroid therapy lowered plasma AVP to normal in dehydrated patients. A normal diuretic response to hydration was accompanied by a fall in plasma AVP to zero in steroid-treated patients. These findings suggest that hypersecretion of AVP may play an important role in the abnormal water metabolism of adrenocortical insufficiency and that the glucosteroids promote normal water diuresis by inhibiting the secretion of AVP from the neurohypophysis.

Browse pages

Click on an image below to see the page. View PDF of the complete article

icon of scanned page 111
page 111
icon of scanned page 112
page 112
icon of scanned page 113
page 113
icon of scanned page 114
page 114
icon of scanned page 115
page 115
icon of scanned page 116
page 116
icon of scanned page 117
page 117
icon of scanned page 118
page 118
icon of scanned page 119
page 119
icon of scanned page 120
page 120
icon of scanned page 121
page 121
icon of scanned page 122
page 122
icon of scanned page 123
page 123
Version history
  • Version 1 (January 1, 1967): No description

Article tools

  • View PDF
  • Download citation information
  • Send a comment
  • Share this article
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal

Metrics

  • Article usage
  • Citations to this article

Go to

  • Top
  • Abstract
  • Version history
Advertisement
Advertisement

Copyright © 2023 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts