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Research Article Free access | 10.1172/JCI105501

Blood Ferrokinetics in Normal Man

Fazle Hosain, George Marsaglia, and Clement A. Finch

Department of Medicine, University of Washington, and the Boeing Scientific Research Laboratories, Seattle, Wash.

†

Present address: Department of Nuclear Medicine, College of Medical Sciences, Banaras Hindu University, Vanarasi 5, U.P., India.

‡

Present address: Boeing Scientific Research Laboratories, Seattle, Wash.

§

Address requests for reprints to Dr. Clement A. Finch, University of Washington School of Medicine, Seattle, Wash. 98105.

*

Submitted for publication January 21, 1966; accepted September 14, 1966.

Investigation supported in part by U. S. Public Health Service research grant 5-RO1-HE-06242 and training grant TI-AM-5130. A portion of this work was conducted through the Clinical Research Center of the University of Washington, supported by the National Institutes of Health (grant FR-37).

Find articles by Hosain, F. in: PubMed | Google Scholar

Department of Medicine, University of Washington, and the Boeing Scientific Research Laboratories, Seattle, Wash.

†

Present address: Department of Nuclear Medicine, College of Medical Sciences, Banaras Hindu University, Vanarasi 5, U.P., India.

‡

Present address: Boeing Scientific Research Laboratories, Seattle, Wash.

§

Address requests for reprints to Dr. Clement A. Finch, University of Washington School of Medicine, Seattle, Wash. 98105.

*

Submitted for publication January 21, 1966; accepted September 14, 1966.

Investigation supported in part by U. S. Public Health Service research grant 5-RO1-HE-06242 and training grant TI-AM-5130. A portion of this work was conducted through the Clinical Research Center of the University of Washington, supported by the National Institutes of Health (grant FR-37).

Find articles by Marsaglia, G. in: PubMed | Google Scholar

Department of Medicine, University of Washington, and the Boeing Scientific Research Laboratories, Seattle, Wash.

†

Present address: Department of Nuclear Medicine, College of Medical Sciences, Banaras Hindu University, Vanarasi 5, U.P., India.

‡

Present address: Boeing Scientific Research Laboratories, Seattle, Wash.

§

Address requests for reprints to Dr. Clement A. Finch, University of Washington School of Medicine, Seattle, Wash. 98105.

*

Submitted for publication January 21, 1966; accepted September 14, 1966.

Investigation supported in part by U. S. Public Health Service research grant 5-RO1-HE-06242 and training grant TI-AM-5130. A portion of this work was conducted through the Clinical Research Center of the University of Washington, supported by the National Institutes of Health (grant FR-37).

Find articles by Finch, C. in: PubMed | Google Scholar

Published January 1, 1967 - More info

Published in Volume 46, Issue 1 on January 1, 1967
J Clin Invest. 1967;46(1):1–9. https://doi.org/10.1172/JCI105501.
© 1967 The American Society for Clinical Investigation
Published January 1, 1967 - Version history
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Abstract

The clearance of radioiron from plasma and its appearance in circulating erythrocytes in normal subjects are studied. The importance of correcting for plasma iron fluctuations and for mean body hematocrit is illustrated. The data are analyzed by probability theory to determine relationships between intravascular and extravascular iron. Two refluxes are described, one of about 7 particles of every 100 leaving the plasma, and the second of about 23. The return times of these are about 5 hours and 8 days, respectively.

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