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Research Article Free access | 10.1172/JCI104925

The Hypoglycemic Action of Ketones. II. Evidence for a Stimulatory Feedback of Ketones on the Pancreatic Beta Cells

Leonard L. Madison, David Mebane, Roger H. Unger, and Amanda Lochner

Department of Internal Medicine, the University of Texas Southwestern Medical School, Dallas, Texas

†

During tenure of U. S. Public Health Service post-doctoral fellowship (APD-17,224) of the National Institute for Arthritis and Metabolic Diseases.

‡

During tenure of a predoctoral fellowship.

*

Submitted for publication August 5, 1963; accepted November 7, 1963.

This work has been supported in large part by U. S. Public Health Service grant A-4236 from the National Institute for Arthritis and Metabolic Diseases and also by grants from the Upjohn and Pfizer Companies.

Presented before the Fifty-Fifth Annual Meeting of the American Society for Clinical Investigation, April 29, 1963.

Find articles by Madison, L. in: PubMed | Google Scholar

Department of Internal Medicine, the University of Texas Southwestern Medical School, Dallas, Texas

†

During tenure of U. S. Public Health Service post-doctoral fellowship (APD-17,224) of the National Institute for Arthritis and Metabolic Diseases.

‡

During tenure of a predoctoral fellowship.

*

Submitted for publication August 5, 1963; accepted November 7, 1963.

This work has been supported in large part by U. S. Public Health Service grant A-4236 from the National Institute for Arthritis and Metabolic Diseases and also by grants from the Upjohn and Pfizer Companies.

Presented before the Fifty-Fifth Annual Meeting of the American Society for Clinical Investigation, April 29, 1963.

Find articles by Mebane, D. in: PubMed | Google Scholar

Department of Internal Medicine, the University of Texas Southwestern Medical School, Dallas, Texas

†

During tenure of U. S. Public Health Service post-doctoral fellowship (APD-17,224) of the National Institute for Arthritis and Metabolic Diseases.

‡

During tenure of a predoctoral fellowship.

*

Submitted for publication August 5, 1963; accepted November 7, 1963.

This work has been supported in large part by U. S. Public Health Service grant A-4236 from the National Institute for Arthritis and Metabolic Diseases and also by grants from the Upjohn and Pfizer Companies.

Presented before the Fifty-Fifth Annual Meeting of the American Society for Clinical Investigation, April 29, 1963.

Find articles by Unger, R. in: PubMed | Google Scholar

Department of Internal Medicine, the University of Texas Southwestern Medical School, Dallas, Texas

†

During tenure of U. S. Public Health Service post-doctoral fellowship (APD-17,224) of the National Institute for Arthritis and Metabolic Diseases.

‡

During tenure of a predoctoral fellowship.

*

Submitted for publication August 5, 1963; accepted November 7, 1963.

This work has been supported in large part by U. S. Public Health Service grant A-4236 from the National Institute for Arthritis and Metabolic Diseases and also by grants from the Upjohn and Pfizer Companies.

Presented before the Fifty-Fifth Annual Meeting of the American Society for Clinical Investigation, April 29, 1963.

Find articles by Lochner, A. in: PubMed | Google Scholar

Published March 1, 1964 - More info

Published in Volume 43, Issue 3 on March 1, 1964
J Clin Invest. 1964;43(3):408–415. https://doi.org/10.1172/JCI104925.
© 1964 The American Society for Clinical Investigation
Published March 1, 1964 - Version history
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