CLINICAL, MORPHOLOGICAL AND BIOCHEMICAL STUDIES OF A VIRILIZING TUMOR IN THE TESTIS

Kenneth Savard; Ralph I. Dorfman; Billy Baggett; Linda L. Fielding; Lewis L. Engel; Harry T. McPherson; Leonard M. Lister; David S. Johnson; Edwin C. Hamblen; Frank L. Engel

doi:10.1172/JCI104067

^{Worcester Foundation for Experimental Biology, Shrewsbury, Mass.}

^{The John Collins Warren Laboratories, Collis P. Huntington Memorial Hospital of Harvard University of Massachusetts General Hospital, and the Department of Biological Chemistry, Harvard Medical School, Boston, Mass.}

^{Department of Medicine, Division of Endocrinology, Duke University Medical Center, Durham, N. C.}

^{Department of Obstetrics and Gynecology, Division of Endocrinology, Duke University Medical Center, Durham, N. C.}

^{Department of Pathology, Division of Endocrinology, Duke University Medical Center, Durham, N. C.}

†

Investigator, Howard Hughes Medical Institute; present address: Departments of Biochemistry and Medicine, University of Miami School of Medicine, Miami, Fla.

‡

Present address: Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, N. C.

Permanent Faculty Fellow of the American Cancer Society.

Present address: University of Maryland School of Medicine, Baltimore, Md.

Present address: Snodgrass Laboratory of Pathology and Bacteriology, St. Louis, Mo.

This work was supported by Contracts no. DA-49-007-MD-184, Army Medical Research and Development Board, Office of the Surgeon General, Department of the Army; no. AT(30-1)-918, United States Atomic Energy Commission and a grant from the Charles A. King Trust. This is Publication no. 990 of the Cancer Commission of Harvard University and was supported by Grants no. CG-1393-C7 and C-2833-C1, United States Public Health Service; P-95(T) American Cancer Society Inc.; and a grant from the Jane Coffin Childs Memorial Fund for Medical Research. Portions of the study on this case have been reported in abstract form in: Fed. Proc. 1956, 15, 346; J clin. Endocr. 1956, 16, 970 and 1629; Abstracts of the Twentieth International Physiological Congress, 1956, Brussels; Expos. ann. Biochim. méd. 1957, 12, 219; Southern Society for Clinical Research, January 25, 1958, New Orleans; Hormone Production in Endocrine Tumors, Ciba Found. Coll. Endocr. 1958, 12, 62.

Find articles by Savard, K. in: JCI | PubMed | Google Scholar

^{Worcester Foundation for Experimental Biology, Shrewsbury, Mass.}

^{Department of Medicine, Division of Endocrinology, Duke University Medical Center, Durham, N. C.}

^{Department of Obstetrics and Gynecology, Division of Endocrinology, Duke University Medical Center, Durham, N. C.}

^{Department of Pathology, Division of Endocrinology, Duke University Medical Center, Durham, N. C.}

†

Investigator, Howard Hughes Medical Institute; present address: Departments of Biochemistry and Medicine, University of Miami School of Medicine, Miami, Fla.

‡

Present address: Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, N. C.

Permanent Faculty Fellow of the American Cancer Society.

Present address: University of Maryland School of Medicine, Baltimore, Md.

Present address: Snodgrass Laboratory of Pathology and Bacteriology, St. Louis, Mo.

Find articles by Dorfman, R. in: JCI | PubMed | Google Scholar

^{Worcester Foundation for Experimental Biology, Shrewsbury, Mass.}

^{Department of Medicine, Division of Endocrinology, Duke University Medical Center, Durham, N. C.}

^{Department of Obstetrics and Gynecology, Division of Endocrinology, Duke University Medical Center, Durham, N. C.}

^{Department of Pathology, Division of Endocrinology, Duke University Medical Center, Durham, N. C.}

†

Investigator, Howard Hughes Medical Institute; present address: Departments of Biochemistry and Medicine, University of Miami School of Medicine, Miami, Fla.

‡

Present address: Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, N. C.

Permanent Faculty Fellow of the American Cancer Society.

Present address: University of Maryland School of Medicine, Baltimore, Md.

Present address: Snodgrass Laboratory of Pathology and Bacteriology, St. Louis, Mo.

Find articles by Baggett, B. in: JCI | PubMed | Google Scholar

^{Worcester Foundation for Experimental Biology, Shrewsbury, Mass.}

^{Department of Medicine, Division of Endocrinology, Duke University Medical Center, Durham, N. C.}

^{Department of Obstetrics and Gynecology, Division of Endocrinology, Duke University Medical Center, Durham, N. C.}

^{Department of Pathology, Division of Endocrinology, Duke University Medical Center, Durham, N. C.}

†

Investigator, Howard Hughes Medical Institute; present address: Departments of Biochemistry and Medicine, University of Miami School of Medicine, Miami, Fla.

‡

Present address: Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, N. C.

Permanent Faculty Fellow of the American Cancer Society.

Present address: University of Maryland School of Medicine, Baltimore, Md.

Present address: Snodgrass Laboratory of Pathology and Bacteriology, St. Louis, Mo.

Find articles by Fielding, L. in: JCI | PubMed | Google Scholar

^{Worcester Foundation for Experimental Biology, Shrewsbury, Mass.}

^{Department of Medicine, Division of Endocrinology, Duke University Medical Center, Durham, N. C.}

^{Department of Obstetrics and Gynecology, Division of Endocrinology, Duke University Medical Center, Durham, N. C.}

^{Department of Pathology, Division of Endocrinology, Duke University Medical Center, Durham, N. C.}

†

Investigator, Howard Hughes Medical Institute; present address: Departments of Biochemistry and Medicine, University of Miami School of Medicine, Miami, Fla.

‡

Present address: Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, N. C.

Permanent Faculty Fellow of the American Cancer Society.

Present address: University of Maryland School of Medicine, Baltimore, Md.

Present address: Snodgrass Laboratory of Pathology and Bacteriology, St. Louis, Mo.

Find articles by Engel, L. in: JCI | PubMed | Google Scholar

^{Worcester Foundation for Experimental Biology, Shrewsbury, Mass.}

^{Department of Medicine, Division of Endocrinology, Duke University Medical Center, Durham, N. C.}

^{Department of Obstetrics and Gynecology, Division of Endocrinology, Duke University Medical Center, Durham, N. C.}

^{Department of Pathology, Division of Endocrinology, Duke University Medical Center, Durham, N. C.}

†

Investigator, Howard Hughes Medical Institute; present address: Departments of Biochemistry and Medicine, University of Miami School of Medicine, Miami, Fla.

‡

Present address: Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, N. C.

Permanent Faculty Fellow of the American Cancer Society.

Present address: University of Maryland School of Medicine, Baltimore, Md.

Present address: Snodgrass Laboratory of Pathology and Bacteriology, St. Louis, Mo.

Find articles by McPherson, H. in: JCI | PubMed | Google Scholar

^{Worcester Foundation for Experimental Biology, Shrewsbury, Mass.}

^{Department of Medicine, Division of Endocrinology, Duke University Medical Center, Durham, N. C.}

^{Department of Obstetrics and Gynecology, Division of Endocrinology, Duke University Medical Center, Durham, N. C.}

^{Department of Pathology, Division of Endocrinology, Duke University Medical Center, Durham, N. C.}

†

Investigator, Howard Hughes Medical Institute; present address: Departments of Biochemistry and Medicine, University of Miami School of Medicine, Miami, Fla.

‡

Present address: Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, N. C.

Permanent Faculty Fellow of the American Cancer Society.

Present address: University of Maryland School of Medicine, Baltimore, Md.

Present address: Snodgrass Laboratory of Pathology and Bacteriology, St. Louis, Mo.

Find articles by Lister, L. in: JCI | PubMed | Google Scholar

^{Worcester Foundation for Experimental Biology, Shrewsbury, Mass.}

^{Department of Medicine, Division of Endocrinology, Duke University Medical Center, Durham, N. C.}

^{Department of Obstetrics and Gynecology, Division of Endocrinology, Duke University Medical Center, Durham, N. C.}

^{Department of Pathology, Division of Endocrinology, Duke University Medical Center, Durham, N. C.}

†

Investigator, Howard Hughes Medical Institute; present address: Departments of Biochemistry and Medicine, University of Miami School of Medicine, Miami, Fla.

‡

Present address: Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, N. C.

Permanent Faculty Fellow of the American Cancer Society.

Present address: University of Maryland School of Medicine, Baltimore, Md.

Present address: Snodgrass Laboratory of Pathology and Bacteriology, St. Louis, Mo.

Find articles by Johnson, D. in: JCI | PubMed | Google Scholar

^{Worcester Foundation for Experimental Biology, Shrewsbury, Mass.}

^{Department of Medicine, Division of Endocrinology, Duke University Medical Center, Durham, N. C.}

^{Department of Obstetrics and Gynecology, Division of Endocrinology, Duke University Medical Center, Durham, N. C.}

^{Department of Pathology, Division of Endocrinology, Duke University Medical Center, Durham, N. C.}

†

Investigator, Howard Hughes Medical Institute; present address: Departments of Biochemistry and Medicine, University of Miami School of Medicine, Miami, Fla.

‡

Present address: Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, N. C.

Permanent Faculty Fellow of the American Cancer Society.

Present address: University of Maryland School of Medicine, Baltimore, Md.

Present address: Snodgrass Laboratory of Pathology and Bacteriology, St. Louis, Mo.

Find articles by Hamblen, E. in: JCI | PubMed | Google Scholar

^{Worcester Foundation for Experimental Biology, Shrewsbury, Mass.}

^{Department of Medicine, Division of Endocrinology, Duke University Medical Center, Durham, N. C.}

^{Department of Obstetrics and Gynecology, Division of Endocrinology, Duke University Medical Center, Durham, N. C.}

^{Department of Pathology, Division of Endocrinology, Duke University Medical Center, Durham, N. C.}

†

Investigator, Howard Hughes Medical Institute; present address: Departments of Biochemistry and Medicine, University of Miami School of Medicine, Miami, Fla.

‡

Present address: Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, N. C.

Permanent Faculty Fellow of the American Cancer Society.

Present address: University of Maryland School of Medicine, Baltimore, Md.

Present address: Snodgrass Laboratory of Pathology and Bacteriology, St. Louis, Mo.

Find articles by Engel, F. in: JCI | PubMed | Google Scholar