Lloyd Hollingsworth Smith Jr.

Known to most of his friends as Holly, Dr. Lloyd Hollingsworth Smith Jr. joins Ushma Neill, JCI Editor at Large, for the next in the journal's series Conversations with Giants in Medicine. He talks about leading the University of California, San Francisco, Department of Medicine as its Chairman for 21 years. During his tenure, Dr. Smith transformed the department into the preeminent West Coast medical school with the highest standards in patient care, teaching, and research. He talks about his early days training in Boston, and about his experiences getting the first artificial kidney to work, both in the hospital and in the Korean War.

Robert Lefkowitz, Joseph Goldstein, and Michael Brown

Three of medicine’s most charismatic giants (Robert Lefkowitz, Joseph Goldstein, and Michael Brown) interview each other. Lefkowitz (Duke University) is known for his seminal discoveries in understanding G protein-coupled receptor function. The legendary partnership between Brown and Goldstein (University of Texas, Southwestern Medical Center) has spanned four decades. Together they were awarded the 1985 Nobel Prize in Physiology or Medicine acknowledging their discovery of the LDL cholesterol receptor and its role in the regulation of cholesterol metabolism. Together, they talk about their beginnings in science, where they got their scientific inspiration, how to be a good mentor, and how to deal with scientific celebrity.

Harold E. Varmus

For the first of our series Conversations with Giants in Medicine, we spoke with Harold E. Varmus, MD, who has been the director of the National Cancer Institute since July 2010. He has previously served as director of the National Institutes of Health (1993–1999) and as president of the Memorial Sloan-Kettering Cancer Center (2000–2010). Among his many awards, Dr. Varmus was awarded the 1989 Nobel Prize in Physiology or Medicine together with J. Michael Bishop in recognition of their discovery of the cellular origin of retroviral oncogenes.