The enigma of sepsis

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Sepsis remains a serious cause of morbidity and mortality, and the pathophysiology of the disease is not clear. The definition of the clinical manifestations of sepsis is ever evolving. This review discusses the search for effective therapeutic interventions, hurdles in translational sepsis research, and new therapies in development in current clinical trials.

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Niels C. Riedemann, Ren-Feng Guo, Peter A. Ward

Monogenic hypercholesterolemia: new insights in pathogenesis and treatment

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Daniel J. Rader, Jonathan Cohen, Helen H. Hobbs

Antimicrobial resistance: the example of Staphylococcus aureus

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Franklin D. Lowy

Intestinal ion transport and the pathophysiology of diarrhea

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Michael Field

The emerging science of body weight regulation and its impact on obesity treatment

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Authors

Judith Korner, Louis J. Aronne

New insights into the pathogenesis of asthma

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Authors

Jack A. Elias, Chun Geun Lee, Tao Zheng, Bing Ma, Robert J. Homer, Zhou Zhu