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New perspectives on the hepatitis B virus life cycle in the human liver
Peter A. Revill, Stephen A. Locarnini
Peter A. Revill, Stephen A. Locarnini
Published February 22, 2016
Citation Information: J Clin Invest. 2016;126(3):833-836. https://doi.org/10.1172/JCI86650.
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Commentary

New perspectives on the hepatitis B virus life cycle in the human liver

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Abstract

The central role of the transcriptional template of the hepatitis B virus (HBV), covalently closed circular DNA (cccDNA), has been difficult to study in patients with chronic hepatitis B (CHB) infection. In this issue of the JCI, Zhang and colleagues reveal a mosaic distribution of viral antigens and nucleic acids and a mismatch between HBV cccDNA, RNA, and expression of the hepatitis B surface antigen (HBsAg). These unusual patterns varied over the natural history of CHB, prompting the authors to propose a new three-stage model of the HBV life cycle at the single-cell level.

Authors

Peter A. Revill, Stephen A. Locarnini

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