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Citation Information: J Clin Invest. 2015;125(1):97-98. https://doi.org/10.1172/JCI79424.
Abstract
Hepatitis C virus (HCV) is a leading cause of chronic liver disease, and efforts to develop therapeutic vaccine strategies have been limited by immune escape due to HCV variants that are resistant to current vaccines or HCV variants that rapidly acquire new resistance-conferring mutations. Recently, the crystal structure of the viral envelope protein E2 region was resolved as well as how E2 docks to the host CD81 protein; therefore, antibodies that block this interaction should prevent viral entry into host cells. In this issue of the
Authors
Jay K. Kolls, Gyongyi Szabo
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