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Sudden death in epilepsy: of mice and men
Daniel Friedman, … , Janice Chyou, Orrin Devinsky
Daniel Friedman, … , Janice Chyou, Orrin Devinsky
Published March 25, 2013
Citation Information: J Clin Invest. 2013;123(4):1415-1416. https://doi.org/10.1172/JCI67759.
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The Attending Physician

Sudden death in epilepsy: of mice and men

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Abstract

A 20-year-old man with intellectual disability and intractable multifocal epilepsy presented to a neurologist for further evaluation and management. His seizures began at 4 months, the night after his first DPT vaccine, and he continued to have frequent tonic-clonic seizures throughout his life. Several weeks after his visit, he was found facedown on the floor, dead, by his family. His autopsy was unremarkable, but genetic testing revealed a frame shift mutation in SCN1A, consistent with severe myoclonic epilepsy of infancy (Dravet syndrome).

Authors

Daniel Friedman, Janice Chyou, Orrin Devinsky

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