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A stimulating way to improve T cell responses to poxvirus-vectored vaccines
Stuart N. Isaacs
Stuart N. Isaacs
Published December 22, 2010
Citation Information: J Clin Invest. 2011;121(1):19-21. https://doi.org/10.1172/JCI45726.
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Commentary

A stimulating way to improve T cell responses to poxvirus-vectored vaccines

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Abstract

Vaccines remain one of the most cost-effective public health measures. Despite ongoing efforts, protective vaccines against cancer and many infectious diseases, including malaria, tuberculosis, and HIV/AIDS, are still not in hand. Most investigators believe that to succeed against these difficult targets, vaccines that generate potent T cell responses are needed. In this issue of the JCI, Salek-Ardakani et al. show how the relative virulence of a virus/vaccine vector affects the memory CD8+ T cells generated and how the response may be enhanced. The work has important implications for the development of future vaccines that aim to trigger CD8+ T cell responses.

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Stuart N. Isaacs

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