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Citation Information: J Clin Invest. 2004;114(3):314-316. https://doi.org/10.1172/JCI22506.
Abstract
Failure of the pancreas to secrete sufficient insulin results in type 2 diabetes, but the pathogenesis of pancreatic β cell dysfunction is still poorly understood. New insights into β cell failure come from defining the genes involved in rare genetic subtypes of diabetes and creating appropriate animal models. A new mouse model of transient neonatal diabetes mellitus emphasizes that both the number of β cells and their function are critical for insulin secretion and may be regulated by imprinted genes.
Authors
Andrew T. Hattersley
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