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Submit a Letter to the Editor

The origin of FOXP3-expressing CD4+ regulatory T cells: thymus or periphery
Shimon Sakaguchi
Shimon Sakaguchi
Published November 1, 2003
Citation Information: J Clin Invest. 2003;112(9):1310-1312. https://doi.org/10.1172/JCI20274.
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Commentary

The origin of FOXP3-expressing CD4+ regulatory T cells: thymus or periphery

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Abstract

Naturally arising CD4+ regulatory T cells, which engage in the maintenance of immunologic self-tolerance, specifically express FOXP3, which encodes a transcription-repressor protein. Genetic defects in FOXP3 cause IPEX, an X-linked autoimmune/inflammatory syndrome. With FOXP3 as a specific marker for regulatory CD4+ T cells in humans, it is now possible to determine their origin and developmental pathway .

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Shimon Sakaguchi

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