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Revealing hyperactivated IFN-γ pathways in perianal fistulizing Crohn’s disease using single-cell and spatial multi-omics
Siyan Cao, … , Parakkal Deepak, SPARC IBD Investigators
Siyan Cao, … , Parakkal Deepak, SPARC IBD Investigators
Published July 3, 2025
Citation Information: J Clin Invest. 2025;135(17):e193413. https://doi.org/10.1172/JCI193413.
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Research Letter Gastroenterology Immunology

Revealing hyperactivated IFN-γ pathways in perianal fistulizing Crohn’s disease using single-cell and spatial multi-omics

Abstract

Authors

Siyan Cao, Khai M. Nguyen, Kaiming Ma, Tingyi Tan, Xin Yao, Ta-Chiang Liu, Malek Ayoub, Jalpa Devi, Sami Samaan, Yizhou Liu, Radhika Smith, Matthew L. Silviera, Steven R. Hunt, Paul E. Wise, Matthew G. Mutch, Sean C. Glasgow, William C. Chapman Jr., Michelle L. Cowan, Matthew A. Ciorba, Marco Colonna, Parakkal Deepak, SPARC IBD Investigators

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