Submit a comment

Production of Erythrocytes that Contain Fetal Hemoglobin in Anemia: TRANSIENT IN VIVO CHANGES
George J. Dover, … , Samuel H. Boyer, William H. Zinkham
George J. Dover, … , Samuel H. Boyer, William H. Zinkham
Published February 1, 1979
Citation Information: J Clin Invest. 1979;63(2):173-176. https://doi.org/10.1172/JCI109286.
View: Text | PDF

Production of Erythrocytes that Contain Fetal Hemoglobin in Anemia: TRANSIENT IN VIVO CHANGES

Abstract

Serial microscopic immunodiffusion assays of F cells, i.e., erythrocytes that contain fetal hemoglobin (HbF), in four individuals recovering from anemia demonstrate initial increases in the percentage of circulating reticulocytes that contain HbF (F reticulocytes) and subsequent increases in the percentage of mature erythrocytes that contain HbF (F erythrocytes). In one individual responding to therapy for iron-deficiency anemia, the average percentage of F reticulocytes increased from 4.8±1.1 to 16.0±2.8% (mean±SD), while the mean level of F erythrocytes increased from 3.5±0.7 to 7.2±0.6%. Two normal children with transient erythroblastopenia exhibited F reticulocyte percentages of 71.3±6.7 and 41.5±1.5%, respectively, when erythropoiesis resumed. With recovery these values fell to finally measured values of 33.7±4.7 and 12.6±1.1%, respectively. In an adolescent with sickle cell anemia, F-reticulocyte percentages fluctuated between 0.6±1.1 and 34.0±2.8% and paralleled the rise and fall of total reticulocytes associated with therapy for a nasopharyngeal carcinoma.

Authors

George J. Dover, Samuel H. Boyer, William H. Zinkham

×

Guidelines

The Editorial Board will only consider comments that are deemed relevant and of interest to readers. The Journal will not post data that have not been subjected to peer review; or a comment that is essentially a reiteration of another comment.

  • Comments appear on the Journal’s website and are linked from the original article’s web page.
  • Authors are notified by email if their comments are posted.
  • The Journal reserves the right to edit comments for length and clarity.
  • No appeals will be considered.
  • Comments are not indexed in PubMed.

Specific requirements

  • Maximum length, 400 words
  • Entered as plain text or HTML
  • Author’s name and email address, to be posted with the comment
  • Declaration of all potential conflicts of interest (even if these are not ultimately posted); see the Journal’s conflict-of-interest policy
  • Comments may not include figures
This field is required
This field is required
This field is required
This field is required
This field is required
This field is required