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Citation Information: J Clin Invest. 1972;51(6):1405-1412. https://doi.org/10.1172/JCI106936.
Abstract
Hypothyroid rats were examined with conventional renal clearance and micropuncture techniques to elicit the mechanism and site within the nephron responsible for the increased salt and water excretion observed in these animals. When compared with age-matched control rats, a decrease in inulin clearance of 30% (P < 0.001) and in Hippuran clearance of 32% (P < 0.005) was observed in the hypothyroid rats. Absolute excretion of sodium and water was increased 3-fold (P < 0.02) and 2-fold (P < 0.025), respectively, while fractional excretion of sodium and water was increased 4.3-fold (P < 0.02) and 2.9-fold (P < 0.05), respectively, in the hypothyroid animals.
Authors
Ulrich F. Michael, Robert L. Barenberg, Rafaelita Chavez, Carlos A. Vaamonde, Solomon Papper
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