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Playing “telephone”: bioactive lipids as mediators of intercompartmental communication in the alveolus
Marc Peters-Golden
Marc Peters-Golden
Published April 1, 2000
Citation Information: J Clin Invest. 2000;105(7):857-858. https://doi.org/10.1172/JCI9724.
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Commentary

Playing “telephone”: bioactive lipids as mediators of intercompartmental communication in the alveolus

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Abstract

Authors

Marc Peters-Golden

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Figure 1

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Scheme for alveolar epithelial to endothelial cell signal propagation in...
Scheme for alveolar epithelial to endothelial cell signal propagation initiated by TNF-α. The spatial interrelationships of participating cells and receptors are shown on the left. The molecular events are summarized on the right. The crucial molecule mediating intercellular communication is free AA, which is hydrolyzed from epithelial cell nuclear membrane phospholipids (PL) by cPLA2, and which induces endothelial cell Ca2+ flux.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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