Schematic depiction of Egr-1 induction in response to mechanical injury to the vessel wall. Egr-1 expression is especially evident in endothelial cells at the wound margin, as well as in the migrating and proliferating smooth muscle cells in the forming neointima. FGF2, as well as other factors yet to be identified, are likely to be involved in Egr-1 induction in this setting.