Insulin replacement is the cornerstone of type 1 diabetes (T1D) treatment; however, glycemic control remains a challenge. Leptin has been shown to effectively restore euglycemia in rodent models of T1D; however, the mechanism or mechanisms by which leptin exerts glycemic control are unclear. In this issue of the
Douglas Oberlin, Christoph Buettner
Model proposed by Perry et al. in this issue to explain the antidiabetic effects of leptin.