JCI - Lessons learned from the development of an Abl tyrosine kinase inhibitor for chronic myelogenous leukemia

Lessons learned from the development of an Abl tyrosine kinase inhibitor for chronic myelogenous leukemia

Published January 1, 2000
Citation Information: J Clin Invest. 2000;105(1):3-7. https://doi.org/10.1172/JCI9083.

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Figure 1

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Structure of the Bcr-Abl gene. The Philadelphia chromosome is formed by a reciprocal translocation between chromosomes 9 and 22. Potential breakpoints are indicated by arrows. This resulting translocation replaces the first exon of c-abl with sequences from the Bcr gene.

Lessons learned from the development of an Abl tyrosine kinase inhibitor for chronic myelogenous leukemia

Lessons learned from the development of an Abl tyrosine kinase inhibitor for chronic myelogenous leukemia

Abstract

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Figure 1

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