The aging clock: circadian rhythms and later life
Suzanne Hood1 and Shimon Amir2
1Department of Psychology, Bishop’s University, Sherbrooke, Quebec, Canada.
2Department of Psychology, Concordia University, Montreal, Quebec, Canada.
Address correspondence to: Shimon Amir, Concordia University, Richard J. Renaud Science Complex, 7141 Sherbrooke West, Montreal, Quebec H4B 1R6, Canada. Phone: 514.848.2424 ext. 2188; E-mail: shimon.amir@concordia.ca.
Find articles by Hood, S. in: JCI | PubMed | Google Scholar
1Department of Psychology, Bishop’s University, Sherbrooke, Quebec, Canada.
2Department of Psychology, Concordia University, Montreal, Quebec, Canada.
Address correspondence to: Shimon Amir, Concordia University, Richard J. Renaud Science Complex, 7141 Sherbrooke West, Montreal, Quebec H4B 1R6, Canada. Phone: 514.848.2424 ext. 2188; E-mail: shimon.amir@concordia.ca.
Find articles by Amir, S. in: JCI | PubMed | Google Scholar
First published February 1, 2017 - More info
J Clin Invest. 2017;127(2):437–446. doi:10.1172/JCI90328.
Copyright © 2017, American Society for Clinical Investigation
Circadian rhythms play an influential role in nearly all aspects of physiology and behavior in the vast majority of species on Earth. The biological clockwork that regulates these rhythms is dynamic over the lifespan: rhythmic activities such as sleep/wake patterns change markedly as we age, and in many cases they become increasingly fragmented. Given that prolonged disruptions of normal rhythms are highly detrimental to health, deeper knowledge of how our biological clocks change with age may create valuable opportunities to improve health and longevity for an aging global population. In this Review, we synthesize key findings from the study of circadian rhythms in later life, identify patterns of change documented to date, and review potential physiological mechanisms that may underlie these changes.
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Copyright © 2017 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)