The secretory protein Dickkopf-1 (DKK-1) is a known Wnt antagonist and has been shown to suppress tumorigenesis in some cancer cells; however, it is also upregulated in many types of cancer and associated with poor prognosis. Wnt-independent mechanisms by which DKK-1 promotes cancer cell proliferation are not well understood. In this issue of the
Dheeraj Bhavanasi, Kelsey F. Speer, Peter S. Klein
DKK-1 stimulates proliferation by binding to CKAP4 and activating AKT.