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Honing a harder-hitting hammerhead improves broadly neutralizing antibody breadth and potency
George K. Lewis
George K. Lewis
Published May 18, 2015
Citation Information: J Clin Invest. 2015;125(6):2271-2274. https://doi.org/10.1172/JCI82057.
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Honing a harder-hitting hammerhead improves broadly neutralizing antibody breadth and potency

Abstract

While current HIV-1 therapies have greatly improved the quality and duration of life for infected individuals, a vaccine to prevent transmission of the virus is lacking. Broadly neutralizing monoclonal antibodies (bnmAbs) with the capacity to neutralize multiple HIV-1 variants have been isolated from HIV-1–infected individuals, and there has been a great effort to investigate how these bnmAbs arise, due their potential for HIV-1 vaccination. In this issue of the JCI, Willis and colleagues apply a computational approach to design variants of the bnmAb PG9 in an attempt to enhance potency and neutralization breadth. One of these variants was able to target multiple PG9-resistant strains, as the result of stabilization of the long heavy chain complementarity determining region 3 (HCDR3). The results of this study provide important insight and a unique approach to optimizing HIV-1 bnmABs.

Authors

George K. Lewis

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