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Chemokines and asthma: redundancy of function or a coordinated effort?
Nicholas W. Lukacs, … , Sandra H.P. Oliveira, Cory M. Hogaboam
Nicholas W. Lukacs, … , Sandra H.P. Oliveira, Cory M. Hogaboam
Published October 15, 1999
Citation Information: J Clin Invest. 1999;104(8):995-999. https://doi.org/10.1172/JCI8125.
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Perspective

Chemokines and asthma: redundancy of function or a coordinated effort?

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Abstract

Authors

Nicholas W. Lukacs, Sandra H.P. Oliveira, Cory M. Hogaboam

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Figure 1

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The ligation of G protein–coupled chemokine receptors induces multiple p...
The ligation of G protein–coupled chemokine receptors induces multiple pathways linked to different G-protein subunits. The classic analysis of chemokine receptor activation is the measurement of Ca2+ flux, but several other pathways exist that may influence cellular activation and mediator production. The α subunit appears to be coupled to at least 4 different pathways that can influence arachidonic acid metabolism, as well as to MAP kinase activation pathways. The other 2 subunits, β and γ, combine to mediate the chemotactic process and initiate the Ser/Thr and Tyr kinase and phosphatase pathways. Altogether, G-protein activation pathways may help to regulate or activate the leukocytes after they become ligated. It is unclear how the activation of specific pathways is managed under different chemokine stimuli.

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