Usage Information

Calcium in atrial fibrillation — pulling the trigger or not?
Nieves Gomez-Hurtado, Björn C. Knollmann
Nieves Gomez-Hurtado, Björn C. Knollmann
View: Text | PDF
Commentary

Calcium in atrial fibrillation — pulling the trigger or not?

Abstract

Atrial fibrillation (AF) is the most common sustained arrhythmia disease. Current drug- and surgical-based therapies are ineffective in about 40% to 50% of AF patients; therefore, there is a great need to better understand the underlying mechanisms of this disease and identify potential therapeutic targets. In this issue of the JCI, Greiser and coworkers discovered that atrial remodeling in response to sustained tachycardia silences Ca2+ signaling in isolated rabbit and human atrial myocytes. This Ca2+ release silencing was attributable to a failure of subcellular propagated Ca2+ release due to an increased cytosolic buffering strength. The results from this study challenge the current paradigm that Ca2+ release instability underlies AF. Instead, Ca2+ silencing could be protective against the massive cellular Ca2+ loading that occurs during chronic AF.

Authors

Nieves Gomez-Hurtado, Björn C. Knollmann

×

Usage data is cumulative from November 2024 through November 2025.

Usage JCI PMC
Text version 627 173
PDF 76 7
Figure 54 0
Citation downloads 58 0
Totals 815 180
Total Views 995

Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

Advertisement