Usage Information

A brain network response to sham surgery
Mariya V. Cherkasova, A. Jon Stoessl
Mariya V. Cherkasova, A. Jon Stoessl
View: Text | PDF
Commentary

A brain network response to sham surgery

Abstract

Evaluation of potential therapies for neurological disease has been challenging due to beneficial responses in patients receiving the sham/placebo treatment. Placebo effects are especially prominent in Parkinson’s disease (PD), which has become a useful model for studying the neurobiology of placebo responses. In this issue of the JCI, Ko and colleagues identify a neural circuit associated with the placebo response in a PD patient cohort. The observed placebo effect–associated pattern involved metabolic activity increases that corresponded with long-term motor improvements after sham surgery. Presurgery activity in this network was inversely related to sham response, suggesting that this network has potential for identifying sham responders and thus reducing placebo-related variance in surgical trials.

Authors

Mariya V. Cherkasova, A. Jon Stoessl

×

Usage data is cumulative from May 2025 through May 2026.

Usage JCI PMC
Text version 580 18
PDF 197 4
Table 93 0
Citation downloads 153 0
Totals 1,023 22
Total Views 1,045

Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

Advertisement