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Usage Information

Autophagy and neurodegeneration
Rebecca A. Frake, … , Fiona M. Menzies, David C. Rubinsztein
Rebecca A. Frake, … , Fiona M. Menzies, David C. Rubinsztein
Published January 2, 2015
Citation Information: J Clin Invest. 2015;125(1):65-74. https://doi.org/10.1172/JCI73944.
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Review

Autophagy and neurodegeneration

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Abstract

Most neurodegenerative diseases that afflict humans are associated with the intracytoplasmic deposition of aggregate-prone proteins in neurons. Autophagy is a powerful process for removing such proteins. In this Review, we consider how certain neurodegenerative diseases may be associated with impaired autophagy and how this may affect pathology. We also discuss how autophagy induction may be a plausible therapeutic strategy for some conditions and review studies in various models that support this hypothesis. Finally, we briefly describe some of the signaling pathways that may be amenable to therapeutic targeting for these goals.

Authors

Rebecca A. Frake, Thomas Ricketts, Fiona M. Menzies, David C. Rubinsztein

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Usage data is cumulative from May 2024 through May 2025.

Usage JCI PMC
Text version 1,581 246
PDF 125 58
Figure 160 3
Table 55 0
Citation downloads 62 0
Totals 1,983 307
Total Views 2,290
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

Various methods are used to distinguish robotic usage. For example, Google automatically scans articles to add to its search index and identifies itself as robotic; other services might not clearly identify themselves as robotic, or they are new or unknown as robotic. Because this activity can be misinterpreted as human readership, data may be re-processed periodically to reflect an improved understanding of robotic activity. Because of these factors, readers should consider usage information illustrative but subject to change.

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