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Usage Information

Pharmacologic agents targeting autophagy
Helin Vakifahmetoglu-Norberg, Hong-guang Xia, Junying Yuan
Helin Vakifahmetoglu-Norberg, Hong-guang Xia, Junying Yuan
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Review

Pharmacologic agents targeting autophagy

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Abstract

Autophagy is an important intracellular catabolic mechanism critically involved in regulating tissue homeostasis. The implication of autophagy in human diseases and the need to understand its regulatory mechanisms in mammalian cells have stimulated research efforts that led to the development of high-throughput screening protocols and small-molecule modulators that can activate or inhibit autophagy. Herein we review the current landscape in the development of screening technology as well as the molecules and pharmacologic agents targeting the regulatory mechanisms of autophagy. We also evaluate the potential therapeutic application of these compounds in different human pathologies.

Authors

Helin Vakifahmetoglu-Norberg, Hong-guang Xia, Junying Yuan

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Usage data is cumulative from July 2025 through July 2026.

Usage JCI PMC
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PDF 303 40
Figure 258 2
Table 333 0
Citation downloads 187 0
Totals 4,042 570
Total Views 4,612
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