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Richard Scheller and Thomas Südhof receive the 2013 Albert Lasker Basic Medical Research Award
Jillian H. Hurst
Jillian H. Hurst
Published September 9, 2013
Citation Information: J Clin Invest. 2013;123(10):4095-4101. https://doi.org/10.1172/JCI72681.
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Richard Scheller and Thomas Südhof receive the 2013 Albert Lasker Basic Medical Research Award

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Jillian H. Hurst

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Figure 1

Starting in the late 1880s, anatomists, including Santiago Ramón y Cajal and Heinrich Wilhelm Gottfried von Waldeyer-Hartz, proposed that the nervous system is made up of individual cells, a concept known as the neuron doctrine, which is illustrated in Ramón y Cajal’s 1899 drawing of Purkinje cells from the pigeon cerebellum (left; image in the public domain).

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Starting in the late 1880s, anatomists, including Santiago Ramón y Cajal...
By the mid-1950s, it was apparent that neurons communicated with each other via chemical synapses. Electron microscopy experiments revealed that neurotransmitters were released from membranous vesicles stored in the nerve endings, as seen in the accompanying electron micrograph (middle and right) (copyright 1973 Rockefeller University Press. Originally published in Journal of Cell Biology. 57:315–344. doi: 10.1083/jcb.57.2.315; ref. 8). It took 40 more years to elucidate the molecular mechanisms that govern neurotransmitter release.
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