Global, sustained production of ROS has deleterious effects on tissue structure and function and gives rise to biochemical and physiological changes associated with organ senescence. Specific, localized ROS metabolites generated by mitochondria and NADPH oxidases also transduce homeostatic information in response to metabolic, mechanical, and inflammatory cues. In this issue of the
Dwight A. Towler
A feed-forward cycle of AMPK-activated mitochondrial metabolism and ROS generation by the kidney reduces diabetes-induced albuminuria.