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Usage Information

The future of molecular chaperones and beyond
Rona G. Giffard, Alberto J.L. Macario, Everly Conway de Macario
Rona G. Giffard, Alberto J.L. Macario, Everly Conway de Macario
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Commentary

The future of molecular chaperones and beyond

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Abstract

Protection of hair cells by HSP70 released by supporting cells is reported by May et al. in this issue of the JCI. Their findings suggest a new way to reduce ototoxicity from therapeutic medications and raise larger questions about the role and integration of heat shock proteins in non–cell-autonomous responses to stress. Increasing evidence suggests an important role for extracellular heat shock proteins in both the nervous system and the immune system. The work also suggests that defective chaperones could cause ear disease and supports the potential use of chaperone therapeutics.

Authors

Rona G. Giffard, Alberto J.L. Macario, Everly Conway de Macario

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Usage data is cumulative from April 2025 through April 2026.

Usage JCI PMC
Text version 413 6
PDF 151 1
Citation downloads 128 0
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Total Views 699
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ISSN: 0021-9738 (print), 1558-8238 (online)

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