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Usage Information

Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer
Jonathan Welti, Sonja Loges, Stefanie Dimmeler, Peter Carmeliet
Jonathan Welti, Sonja Loges, Stefanie Dimmeler, Peter Carmeliet
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Science in Medicine

Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer

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Abstract

Four decades ago, angiogenesis was recognized as a therapeutic target for blocking cancer growth. Because of its importance, VEGF has been at the center stage of antiangiogenic therapy. Now, several years after FDA approval of an anti-VEGF antibody as the first antiangiogenic agent, many patients with cancer and ocular neovascularization have benefited from VEGF-targeted therapy; however, this anticancer strategy is challenged by insufficient efficacy, intrinsic refractoriness, and resistance. Here, we examine recent discoveries of new mechanisms underlying angiogenesis, discuss successes and challenges of current antiangiogenic therapy, and highlight emerging antiangiogenic paradigms.

Authors

Jonathan Welti, Sonja Loges, Stefanie Dimmeler, Peter Carmeliet

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Usage data is cumulative from June 2025 through June 2026.

Usage JCI PMC
Text version 1,893 85
PDF 267 24
Figure 776 7
Table 177 0
Supplemental data 94 6
Citation downloads 145 0
Totals 3,352 122
Total Views 3,474
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ISSN: 0021-9738 (print), 1558-8238 (online)

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