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Usage Information

Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer
Jonathan Welti, … , Stefanie Dimmeler, Peter Carmeliet
Jonathan Welti, … , Stefanie Dimmeler, Peter Carmeliet
Published August 1, 2013
Citation Information: J Clin Invest. 2013;123(8):3190-3200. https://doi.org/10.1172/JCI70212.
View: Text | PDF
Science in Medicine

Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer

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Abstract

Four decades ago, angiogenesis was recognized as a therapeutic target for blocking cancer growth. Because of its importance, VEGF has been at the center stage of antiangiogenic therapy. Now, several years after FDA approval of an anti-VEGF antibody as the first antiangiogenic agent, many patients with cancer and ocular neovascularization have benefited from VEGF-targeted therapy; however, this anticancer strategy is challenged by insufficient efficacy, intrinsic refractoriness, and resistance. Here, we examine recent discoveries of new mechanisms underlying angiogenesis, discuss successes and challenges of current antiangiogenic therapy, and highlight emerging antiangiogenic paradigms.

Authors

Jonathan Welti, Sonja Loges, Stefanie Dimmeler, Peter Carmeliet

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Usage data is cumulative from June 2024 through June 2025.

Usage JCI PMC
Text version 1,363 108
PDF 150 31
Figure 364 5
Table 55 0
Supplemental data 39 1
Citation downloads 101 0
Totals 2,072 145
Total Views 2,217
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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