Embryonic stem cells (ESCs) hold great therapeutic promise for the regeneration of functional cell types and clinical applications. However, tumorigenic potential of stem cells in a transplanted host remains a major obstacle. In this issue of the
Hong Ouyang, Yehong Zhuo, Kang Zhang
Canonical WNT signaling determines the proliferation and differentiation state of ESC-derived progenitors via full-length TCF7 (fTCF7).