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Usage Information

Anonymous sources: where do adult β cells come from?
Michael S. German
Michael S. German
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Commentary

Anonymous sources: where do adult β cells come from?

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Abstract

Evidence that the pool of insulin-producing β cells in the pancreas is reduced in both major forms of diabetes mellitus has led to efforts to understand β cell turnover in the adult pancreas. Unfortunately, previous studies have reached opposing conclusions regarding the source of new β cells during regeneration in the adult pancreas. In this issue of the JCI, Xiao et al. use a novel mouse model for detecting new β cells derived from non–β cells to demonstrate the absence of β cell neogenesis from non–β cells during normal postnatal growth and in models of β cell regeneration. This work adds to mounting evidence that in most physiological and pathological conditions, β cell neogenesis may not make large contributions to the postnatal β cell pool — at least not in rodents.

Authors

Michael S. German

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Usage data is cumulative from October 2025 through October 2026.

Usage JCI PMC
Text version 509 8
PDF 297 3
Figure 165 0
Citation downloads 213 0
Totals 1,184 11
Total Views 1,195
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ISSN: 0021-9738 (print), 1558-8238 (online)

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