Desmoglein-1 (DSG1), a desmosomal protein, maintains the structure of epidermis through its adhesive function. However, heterozygous mutations in DSG1 in humans result in abnormal differentiation, as does downregulation of DSG1 in human skin organ culture, suggesting that it may have important signaling functions. In this issue of the
Christoph M. Hammers, John R. Stanley
Keratinocyte structure, adhesion, and signaling modulated by Erbin and/or DSG1.