BMT model employed to study contribution of postnatal vasculogenesis to neovascularization of ischemic tissues. Transgenic mouse constitutively expressing LacZ gene transcriptionally regulated by an EC-specific promoter, Flk-1 or Tie-2, is used as BM donor. BM is harvested and transplanted to mouse of same genetic background, in which BM has been sublethally irradiated. After a period of 4 weeks to allow for reconstitution of transplanted BM, recipient mouse undergoes one or more interventions, all of which are intended to serve as stimulus for neovascularization. At arbitrarily selected time points following these interventions, animals are sacrificed and the respective tissues stained with X-gal to histologically identify cells in which expression of β-galactosidase produces blue cells. Use of an EC-specific promoter permits identification of blue cells, which have incorporated into foci of neovascularization as endothelial lineage cells.