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Usage Information

Linking endothelial dysfunction with endothelial cell activation
James K. Liao
James K. Liao
Published February 1, 2013
Citation Information: J Clin Invest. 2013;123(2):540-541. https://doi.org/10.1172/JCI66843.
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Hindsight

Linking endothelial dysfunction with endothelial cell activation

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Abstract

The thin layer of cells that lines the interior of blood vessels, known as the endothelium, plays a complex role in vascular biology. The endothelium mediates blood vessel tone, hemostasis, neutrophil recruitment, hormone trafficking, and fluid filtration. Endothelial dysfunction, as defined by a lack of NO, has been linked to a variety of disease states, including atherosclerosis, diabetes mellitus, coronary artery disease, hypertension, and hypercholesterolemia. Indeed, restoration of endothelial function is one of the earliest recognizable benefits of statin therapy. In 1995, James Liao and colleagues published a study in the JCI demonstrating that NO is a vascular protective factor that limits endothelial activation and prevents leukocyte adhesion to the vessel wall.

Authors

James K. Liao

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Usage data is cumulative from August 2021 through August 2022.

Usage JCI PMC
Text version 2,182 1,012
PDF 335 144
Figure 313 7
Citation downloads 37 0
Totals 2,867 1,163
Total Views 4,030
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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