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Molecules in motion: Michael Sheetz, James Spudich, and Ronald Vale receive the 2012 Albert Lasker Basic Medical Research Award
Sarah Jackson
Sarah Jackson
Published September 10, 2012
Citation Information: J Clin Invest. 2012;122(10):3374-3377. https://doi.org/10.1172/JCI66361.
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Molecules in motion: Michael Sheetz, James Spudich, and Ronald Vale receive the 2012 Albert Lasker Basic Medical Research Award

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Sarah Jackson

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Figure 4

Kinesins generate anterograde movement in cells.

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Kinesins generate anterograde movement in cells.
Fueled by an interest i...
Fueled by an interest in how nerves conduct long-distance transport, Ronald Vale and Michael Sheetz examined force-generating proteins in extracts from squid axons. They found that movement occurred along microtubule tracks and discovered kinesin as the molecular motor that drives movement from the cell body to the periphery (10). Another motor protein, dynein (not shown), is responsible for retrograde transport in the opposite direction (11, 12).
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