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Abstract
The incidence of melanoma — the most aggressive form of skin cancer — is dramatically increasing, while the development of innovative therapeutic strategies continues to be challenging, especially due to a lack of knowledge about the molecular mechanisms underlying melanoma progression as well as antitumor immunity. In this issue of the JCI, Yong Lu and colleagues report a central role for Th9 cells in antitumor immunity.
Authors
Edgar Schmitt, Tobias Bopp
Figure 1
Effector functions of Th9 cells in antitumor immune responses.
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Th9-derived IL-9 can have direct antitumor effects or can indirectly influence tumor growth by altering immune responses. IL-9 induces the production of CCL20 in lung epithelial cells, which mediates the recruitment of CCR6-expressing DCs and CD8+ CTLs. In addition, the MEA of IL-9 could further potentiate the induction of an adaptive antitumor immune response by providing mast cell–derived IL-1β and TNF-α. IL-9R, IL-9 receptor.
Copyright © 2023 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)