Taking a bite: endocytosis in the maintenance of the slit diaphragm
Rosemary V. Sampogna, Qais Al-Awqati
Rosemary V. Sampogna, Qais Al-Awqati
Published November 26, 2012
Citation Information: J Clin Invest. 2012;122(12):4330-4333. https://doi.org/10.1172/JCI65785.
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Commentary

Taking a bite: endocytosis in the maintenance of the slit diaphragm

Abstract

In the kidney, the slit diaphragm joins adjacent podocytes, forming an epithelial barrier that filters plasma into the urinary space, yet retains blood cells and proteins within the circulation. In this issue of the JCI, Soda et al. have identified clathrin-mediated endocytosis as a central mechanism by which the function and structural integrity of the slit diaphragm are maintained.

Authors

Rosemary V. Sampogna, Qais Al-Awqati

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Figure 1

Podocytes and the slit diaphragm.

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Podocytes and the slit diaphragm. Schematic of neighboring podocytes att...
Schematic of neighboring podocytes attached to the GBM, with key cell-cell adhesion proteins, including nephrin, Neph-1, P-cadherin, and the protocadherins FAT1 and FAT2.