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Usage Information

The attachment disorders of muscle: failure to carb-load
Elizabeth M. McNally
Elizabeth M. McNally
Published August 27, 2012
Citation Information: J Clin Invest. 2012;122(9):3046-3048. https://doi.org/10.1172/JCI65483.
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Commentary

The attachment disorders of muscle: failure to carb-load

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Abstract

Dystroglycan is a prominent cell surface protein that mediates attachment to the extracellular matrix. Although broadly expressed, glycosylated dystroglycan is critically important for muscle cell adherence to its surrounding matrix. A subgroup of muscular dystrophies, which often manifest in infancy, is associated with reduced glycosylation of dystroglycan. In this issue of the JCI, Beedle et al. used conditional gene targeting of Fktn, the gene responsible for Fukuyama congenital muscular dystrophy, to investigate a developmental requirement for glycosylation of dystroglycan.

Authors

Elizabeth M. McNally

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