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Usage Information

TLRs and IFNs: critical pieces of the autoimmunity puzzle
Argyrios N. Theofilopoulos
Argyrios N. Theofilopoulos
Published October 1, 2012
Citation Information: J Clin Invest. 2012;122(10):3464-3466. https://doi.org/10.1172/JCI63835.
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Hindsight

TLRs and IFNs: critical pieces of the autoimmunity puzzle

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Abstract

Discoveries revealing the molecular basis of innate immune responses, particularly the identification of Toll-like receptors (TLRs) as the major recognition sensors for microbial and even self-molecules, have provided new insights into the pathogenesis of both systemic and organ-specific autoimmune diseases. These insights will permit the development of novel treatment modalities for these disorders.

Authors

Argyrios N. Theofilopoulos

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