Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Alerts
  • Advertising
  • Job board
  • Subscribe
  • Contact
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Author's Takes
  • Reviews
    • View all reviews ...
    • Immune Environment in Glioblastoma (Feb 2023)
    • Korsmeyer Award 25th Anniversary Collection (Jan 2023)
    • Aging (Jul 2022)
    • Next-Generation Sequencing in Medicine (Jun 2022)
    • New Therapeutic Targets in Cardiovascular Diseases (Mar 2022)
    • Immunometabolism (Jan 2022)
    • Circadian Rhythm (Oct 2021)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Commentaries
    • Research letters
    • Letters to the editor
    • Editorials
    • Viewpoint
    • Top read articles
  • Clinical Medicine
  • JCI This Month
    • Current issue
    • Past issues

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Author's Takes
  • In-Press Preview
  • Commentaries
  • Research letters
  • Letters to the editor
  • Editorials
  • Viewpoint
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Alerts
  • Advertising
  • Job board
  • Subscribe
  • Contact
TLRs and IFNs: critical pieces of the autoimmunity puzzle
Argyrios N. Theofilopoulos
Argyrios N. Theofilopoulos
Published October 1, 2012
Citation Information: J Clin Invest. 2012;122(10):3464-3466. https://doi.org/10.1172/JCI63835.
View: Text | PDF
Hindsight

TLRs and IFNs: critical pieces of the autoimmunity puzzle

  • Text
  • PDF
Abstract

Discoveries revealing the molecular basis of innate immune responses, particularly the identification of Toll-like receptors (TLRs) as the major recognition sensors for microbial and even self-molecules, have provided new insights into the pathogenesis of both systemic and organ-specific autoimmune diseases. These insights will permit the development of novel treatment modalities for these disorders.

Authors

Argyrios N. Theofilopoulos

×

Figure 1

The two-phase paradigm for lupus pathogenesis.

Options: View larger image (or click on image) Download as PowerPoint
The two-phase paradigm for lupus pathogenesis.
In the initiation phase (...
In the initiation phase (i), self–nucleic acids and associated proteins in apoptotic cell debris are taken up by DCs and nontolerant B cells with specific BCRs, leading to endosomal TLR engagement, production of type I IFNs, antigen presentation to helper T cells, and production of autoantibodies. In the amplification phase (ii), autoantibodies complexed with particles containing nucleic acids and proteins are taken up by pDCs, DCs, and B cells, thereby creating an autoamplification loop that sustains the pathogenic response. In some instances, recognition of nucleic acids may be mediated by cytosolic sensors, and microbial nucleic acids may also precipitate these events.

Copyright © 2023 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts