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Usage Information

“Snorkeling” for missing players in cancer
Riccardo Taulli, Pier Paolo Pandolfi
Riccardo Taulli, Pier Paolo Pandolfi
Published July 2, 2012
Citation Information: J Clin Invest. 2012;122(8):2765-2768. https://doi.org/10.1172/JCI63549.
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Commentary

“Snorkeling” for missing players in cancer

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Abstract

Small nucleolar RNAs (snoRNAs) are emerging as an important new class of genes deregulated in cancer. Orphans snoRNAs are encoded outside of ribosomal protein genes and are involved in either gene splicing or are microRNA precursors. In this issue of JCI, Chu et al. find that ACA11, an orphan snoRNA encoded in an intron of the WHSC1 gene, is aberrantly overexpressed in t(4;14)-positive patients with multiple myeloma (MM), in which it influences growth of MM cells, resistance to chemotherapy, and oxidative stress. These findings represent the first identification of a snoRNA overexpressed as a consequence of a chromosomal translocation, a potent driving force of the neoplastic process in general and hematopoietic malignancies in particular.

Authors

Riccardo Taulli, Pier Paolo Pandolfi

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Usage data is cumulative from June 2024 through June 2025.

Usage JCI PMC
Text version 340 16
PDF 70 16
Figure 72 2
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Usage information is collected from two different sources: this site (JCI) and Pubmed Central (PMC). JCI information (compiled daily) shows human readership based on methods we employ to screen out robotic usage. PMC information (aggregated monthly) is also similarly screened of robotic usage.

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